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Since TFR1 mediates the main route of iron entry into neurons via the Tf-TFR1 complex, HIF-1-dependent TFR1 induction leads to iron influx and overload within neurons (134)

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The pharmaceutical preparation that parenteral is used comprises the aqueous solution of the reactive compound that exists with water-soluble form.In addition, can with the suspension preparation of reactive compound suitable oily injectable suspensions.Suitable lipophilic solvent or vehicle comprise for example for example ethyl oleate or triglyceride of Oleum sesami or synthetic fatty acid esters of fatty oil, or liposome.The material that water injection suspension liquid can comprise the viscosity that increases suspension is sodium carboxymethyl cellulose, sorbitol or glucosan for example.Randomly, suspension also can comprise suitable stabilizing agent or increase the reagent of the stability of chemical compound with the highly enriched liquid of permission preparation

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Tanphaichitr VS, Pung-amrit P, Yodthong S, Soongswang J, Mahasandana C, Suvatte V: Glucose-6-phosphate dehydrogenase deficiency in the newborn: its prevalence and relation to neonatal jaundice